Efficacy of triclabendazole and albendazole against Fasciola spp. infection in cattle in Côte d'Ivoire: a randomised blinded trial

Triclabendazole is the anthelminthic of choice for treatment fascioliasis, however, it only registered in a few countries. We investigated efficacy single-dose triclabendazole (12 mg/kg) or albendazole (15 against Fasciola spp. infection cattle on farms northern part Côte d'Ivoire randomized clinical trial. Faecal samples were obtained from 196 cattle, which 155 (79.1%) found positive by sedimentation technique. Cattle infected with randomly allocated (3:3:1) to receive (n = 66), 67) left untreated serve as control 22). Follow-up faecal collected days 21, 28, 90 and 188 post-treatment. No adverse events observed reported farmers any groups. The proportion non-egg shedding assessed at day 21 (primary outcome), was significantly higher treated (95.4%) compared those receiving (70.3%; odds ratio [OR] 8.73, 95% confidence interval [CI] 2.43-31.28, p <0.001). egg reduction rate (ERR) expressed number eggs per gram faeces, secondary endpoint post-treatment, arm (arithmetic mean (AM) ERR 99.8%) than (AM 92.2%), difference 7.6%-points (95% CI: 0.9-14.5%-points, p=0.026). This first report naturally d'Ivoire. Our results confirm that most effective fascioliasis therefore, should be considered livestock fascioliasis; if resources allow combination intermediate host snail raising awareness pasture management avoid reinfection.